Dysregulated Resolution of Inflammation in Atherosclerosis: Mechanistic Insights and Therapeutic Opportunities.

Natural Products Modulate Plaque Macrophage Functional Programs in Atherosclerosis

Abstract Atherosclerosis is a chronic inflammatory and immunometabolic disease in which plaque macrophages integrate lipid-derived danger signals, metabolic stress and cell-death cues to shape foam-cell formation, necrotic-core expansion, fibrous-cap integrity and plaque vulnerability. Moving beyond the conventional M1...

Neutrophil Extracellular Traps in Atherosclerosis and Cardiovascular Disease

A framework highlights NETs as both mechanistic drivers and promising therapeutic targets in atherosclerotic cardiovascular disease and describes the molecular mechanisms of NET formation and the cooperative actions of NET components as an integrated thrombo‐inflammatory platform.

Beyond Inflammation: The NLRP3 Inflammasome as a Cellular and Mechanical Hub of Vascular Remodeling in Hypertension.

Neutrophil extracellular traps in cardiovascular disease: Mechanisms and therapeutic implications (Review)

The present review systematically delineated the interaction networks between NETs and macrophages, monocytes, endothelial cells, fibroblasts and platelets, untangling NETs as a central hub that integrates the pathological triad of inflammation, thrombosis and fibrosis in cardiovascular diseases.

Innate immunity and hypertension: unveiling inflammatory pathways for novel therapies

Hypertension is a leading cause of global cardiovascular morbidity and mortality, yet its primary etiology remains poorly defined. Accumulating evidence increasingly positions inflammation as a key determinant of disease progression, with both innate and adaptive immune mechanisms playing central roles. Under physiolog...

From atherosclerosis to reperfusion injury: a comprehensive review of neutrophil extracellular traps across the spectrum of coronary heart disease

Neutrophil extracellular traps (NETs) have emerged as critical mediators in the pathogenesis of coronary heart disease (CHD), linking innate immunity, thrombosis, and vascular inflammation. This review offers a comprehensive overview of NETs across the spectrum of CHD, ranging from chronic atherosclerotic plaque develo...