SLC2A3 knockdown enhances radiosensitivity and suppresses MAPK signaling in nasopharyngeal carcinoma

Abstract

Highlights • Silencing SLC2A3 reduces the malignant phenotypes of irradiated NPC cells.• SLC2A3 knockdown decreases tumorigenicity in irradiated NPC xenograft-bearing mice.• SLC2A3 knockdown enhances NPC cell radiosensitivity, partly in association with reduced MAPK pathway activation.