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Review Sep 2026

Research progress on metabolic engineering for efficient squalene synthesis in yeast cell factories

Significant advances in integrated strategies, particularly organelle engineering in Yarrowia lipolytica and Saccharomyces cerevisiae, have increased squalene titers to high levels and provide a useful basis for future metabolic engineering efforts aimed at improving squalene production and facilitating the synthesis o...

Chen Yang, Chuan-Bo Zhang, Wen-Yu Lu · 0 citations
Aug 2026

Alleviating the Crabtree Effect for High-Level Production of Squalene in Saccharomyces cerevisiae.

Saccharomyces cerevisiae is a widely used biomanufacturing chassis; however, its inherent Crabtree effect severely limits energy yield and diverts carbon flux away from the desired non-ethanol products. To address this challenge, we developed a multidimensional metabolic engineering strategy to alleviate the Crabtree e...

Shuyan Tang, Wenzhuo Gao, Jia-Ying Wang et al. · 1 citation · ⚡1
Review Sep 2026

Recent Advances in the Production and Biosynthesis of Oleanane-Type Pentacyclic Triterpenoids.

Oleanane-type pentacyclic triterpenoids are a class of naturally occurring specialized metabolites with diverse biological activities. Conventional plant extraction and chemical synthesis are constrained by low yields, high costs, and a reliance on natural resources. With the development of synthetic biology and metabo...

Fu-Yan Yuan, De-Yue Diao, Shi-Xiang Peng et al. · 0 citations
Review Sep 2026

The isopentenol utilization pathway: enzyme engineering, metabolic integration, and applications in microbial terpenoid biosynthesis.

This review treats the isopentenol utilization pathway as a configurable precursor module rather than a single pathway variant, and identifies the regimes, and the quantitative margins, within which an alcohol-fed bypass outperforms further MVA or MEP optimization.

Y. Kim, Youngwoo Na, Won Yoon Hwan Choi et al. · 0 citations
Review Open access Aug 2026

Toward Complex Polyketide Biosynthesis in Yarrowia lipolytica via Metabolic Reprogramming

Polyketides are among the most structurally diverse and therapeutically important classes of natural products, serving as antibiotics, anticancer agents, agrochemicals, and industrial pigments. Their structural complexity and limited natural availability have driven the development of microbial biosynthetic platforms a...

Kian Ghaempanah, So-Hee Son, Ju-Young Lee · 0 citations
Review Open access Aug 2026

Push–pull–block framework for lycopene biosynthesis: a comprehensive review of metabolic engineering strategies in Saccharomyces cerevisiae

Lycopene is a high-value carotenoid widely utilized in food, pharmaceutical, nutraceutical, and cosmetic industries because of its strong antioxidant properties and associated health benefits. Among microbial hosts, Saccharomyces cerevisiae has emerged as a promising platform for sustainable lycopene biosynthesis due t...

Farah D. Garaad, H. Karaca · 0 citations

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