An Insect Chitosan/Konjac Glucomannan Multifunctional Photo-Cross-Linking Hydrogel Loaded with a Baicalin Nanodelivery System for Promoting MRSA-Infected Diabetic Wound Healing.
This study developed a dual-cross-linked photopolymerizable hydrogel (Q/O/Z@B/UV) for treating MRSA-infected diabetic wounds that significantly accelerated wound closure, promoted collagen deposition, suppressed inflammatory factor expression, and enhanced angiogenesis.
Abstract
Traditional wound dressings such as gauze and bandages cannot adequately handle the complex biological features of diabetic wounds, including increased bacterial infection risk and persistent inflammation. Therefore, creating multifunctional wound dressings with diverse biological activities is an essential clinical strategy. This study developed a dual-cross-linked photopolymerizable hydrogel (Q/O/Z@B/UV) for treating MRSA-infected diabetic wounds. The hydrogel integrates a network of quaternized insect chitosan and methacrylate-oxidized konjac glucomannan with a baicalin-modified zeolitic imidazolate framework-8 nanosystem. The resulting hydrogels exhibit excellent mechanical properties, biocompatibility, degradability, hemostatic effects, and antimicrobial activity. The Z@B system further enhances antibacterial, antioxidant, and anti-inflammatory activities and also promotes cell proliferation and differentiation. In a full-thickness skin defect model using MRSA-infected diabetic rats, Q/O/Z@B/UV significantly accelerated wound closure, promoted collagen deposition, suppressed inflammatory factor expression, and enhanced angiogenesis. Overall, this multifunctional hydrogel shows great potential for treating MRSA-infected diabetic wounds.
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It is demonstrated that the catechol-nanocellulose/chitosan polymeric hydrogel effectively overcomes adhesion, infection, and oxidative stress barriers in diabetic wound healing, making it a promising candidate for difficult-to-heal chronic ulcers.
Conventional wound dressings often fail to integrate rapid hemostasis, antibacterial protection, and a pro-regenerative microenvironment, leading to persistent infection and delayed healing in complex wounds. Herein, we report a multifunctional self-adhesive hydrogel for integrated hemostatic, antibacterial, and regenerative wound management with a synergistic dual-crosslinked network. The hydrogel is composed of methylacrylamide-modified type I collagen (ColMA), o-nitrobenzene-modified hyaluronic acid (HANB), and methylacrylamide-modified chitosan (CSMA), and can rapidly form in situ under UV irradiation through free-radical polymerization of methacrylamide groups and Schiff base reactions between HANB and amino groups on ColMA/CSMA. Once applied to infected wounds, the hydrogel rapidly seals the wound bed and adheres tightly to the tissue, where HANB contributes hemostatic and adhesive properties, CSMA provides intrinsic antibacterial activity to inhibit bacterial colonization, and ColMA offers extracellular matrix-mimicking cues to support cell adhesion and tissue regeneration. Through this coordinated mechanism, the hydrogel not only controls bleeding and reduces infection risk at the early stage but also promotes the growth of granulation tissue, re-epithelialization, and matrix reconstruction during the subsequent repair phase. This platform integrates wound closure, antibacterial defense, and tissue regeneration into a single dressing system, acting as a promising strategy for the treatment of infected wounds.
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A multifunctional composite hydrogel (GelDA/OPL) with excellent adhesion, self-healing properties, injectability, and photothermal antibacterial activity through Schiff base crosslinking between dopamine-modified gelatin (GelDA) and oxidized pullulan (OPL) is constructed.
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This work demonstrates a safe and effective strategy for combating MDR infections through the combined action of photothermal therapy and nanozyme catalysis, offering promising potential for clinical wound management.
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