Synthesis, Characterization, and Investigation of Biological Effects of Some New 1,2-Thiazine Derivatives

Abstract

Nanomaterials and their applications hold a promise for widespread use in agriculture, medicine, and industry. This research article explores the synthesis of some new 1,2-thiazine derivatives, highlighting their potential as antibacterial agents. In this work, a key innovation in this work is the development of a cost-effective, sustainable and environmentally friendly method for creating copper nanoparticles. These nanoparticles were synthesized using a green chemistry approach with an extract from Ziziphus mauritiana fruit, and were successfully used to improve the efficiency of the Ullmann coupling reaction. In the synthesized copper nanoparticles, enhancing of Ullmann coupling was shown to significantly improve in the synthesis of 1,2-thiazine derivatives. Furthermore, the study further investigated the oxidation of methyl groups on the thiazine ring. This oxidation led to convert of methyl group into aldehyde group. Several of the synthesized compounds demonstrated significant antibacterial activity against both Gram-positive bacteria, specifically Staphylococcus aureus, and Gram-negative bacteria, such as Escherichia coli. These findings suggest that copper nanoparticles could serve as a promising foundation for developing new antibacterial agents, potentially offering an effective and more natural alternative to conventional antimicrobial treatments. Moreover, this research provides a scientific pathway for the use of these compounds and nanoparticles in the pharmaceutical industry for the development of new drugs.