ABSTRACT INTRODUCTION Pembrolizumab has been widely used since its approval as perioperative therapy for triple-negative breast cancer. While the emergence of diverse antibody drugs has expanded therapeutic options in recent years, reports on the combined use of immune-related antibodies in patients with other diseases...
Haruna Iriyama, M. Iwase, Yuko Takano et al.· Surgery Case Reports· 0 citations
The case concerns a 68-year-old female patient with metastatic HR-positive/HER2-negative pleomorphic lobular breast carcinoma and severe chronic renal impairment since diagnosis, previously treated with multiple lines of therapy. At diagnosis in September 2021, the disease was already metastatic, with bone, nodal, and...
C. Martinelli· Recenti progressi in medicin...· 0 citations
A 65-years-old woman underwent right mastectomy in 2010 for invasive ductal carcinoma of the breast (HR=95% PgR=18% ki67= 25% HER2= 0). Stage pT2(30mm)pN1(2/10)M0. She started adjuvant chemotherapy then endocrine therapy. In March 2021 a CT scan showed suspected right breast and axillary lymph node recurrence; a biopsy...
L. Scortichini, N. Battelli· Recenti progressi in medicin...· 0 citations
In this real-world Middle Eastern cohort, pembrolizumab-based chemoimmunotherapy achieved pCR rates consistent with pivotal trial data, and Grade 3 histology, pathogenic germline mutation, and age younger than 40 years were independently associated with pCR.
B. Sharaf, T. Al-Batsh, Suhaib Khater et al.· Breast Cancer· 0 citations
As pembrolizumab has been widely used in the immunotherapy of various solid tumors such as melanoma and lung cancer, reports of pembrolizumab-related adverse drug events have gradually attracted attention; however, cases of pembrolizumab-induced fulminant type 1 diabetes mellitus (FT1DM) remain rare. This article repor...
Shu-Jun Sun, Liang Su, Xiao-Jing Ma et al.· Frontiers in Endocrinology· 0 citations
Gains in event-free and overall survival from the KEYNOTE-522 trial have incorporated pembrolizumab into the neoadjuvant and adjuvant armamentarium for stage II-III triple-negative breast cancer (TNBC). However, the lack of a second randomization to pembrolizumab after surgery raises the question of whether the adjuvan...
V. Liutti, H. Wildiers, G. Sonke et al.· European Journal of Cancer· 0 citations
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