Boosted training strategy for physics-informed neural networks in modeling non-linear computer virus dynamics with vertical transmission

Fractional physics-informed neural network approach to inverse problems in epidemiological modeling

This study proposes a Fractional-Order Physics-Informed Neural Network (FPINN) framework for solving inverse parameter estimation problems in both fractional SIR and augmented SEIR epidemiological models and demonstrates that the proposed method accurately reconstructs epidemic trajectories and captures the influence of memory effects on disease evolution.

Physics-Informed Neural Networks (PINNs) for Parameter Estimation in the SIRS-D Epidemiological Model

Infectious diseases exhibit complex and rapidly evolving transmission dynamics, requiring modeling approaches that can accurately capture these mechanisms. The SIRS-D compartmental model provides a suitable framework, as it incorporates temporary immunity and disease-induced mortality within the epidemic process. Accurate parameter estimation is essential for quantifying the transmission rate, recovery rate, waning immunity rate, and mortality rate, which collectively govern the system behavior. Among existing estimation methods, Physics-Informed Neural Networks (PINNs) offer significant advantages by integrating observational data with the underlying structure of differential equations, thereby preserving physical consistency while maintaining robustness under imperfect data conditions. In this study, PINNs are employed to estimate the parameters of the SIRS-D model using synthetic data generated through the fourth-order Runge–Kutta (RK4) method to ensure stable and consistent numerical solutions. To better represent real-world measurement conditions, 5% noise is added to the synthetic data, introducing realistic variability into the training process. The results demonstrate that PINNs successfully reconstruct the trajectories of S(t), I(t), R(t), and D(t) with low prediction errors. The model achieves MAE values of 0.0065 (S), 0.0067 (I), 0.0208 (R), and 0.0043 (D), with corresponding RMSE values of 0.0090, 0.0074, 0.0253, and 0.0058. Moreover, the estimated parameters closely match the true values, yielding ????????=0.5031, ????=0.0996, ????=0.0095, and ????=0.0149, demonstrating strong parameter identification capability. These findings confirm that PINNs constitute a reliable and accurate framework for analyzing infectious disease dynamics and offer promising potential for extension to more complex epidemiological models and real-world datasets.

Physics-Informed Stochastic Configuration Machine: A Backpropagation-Free Neural Network with Fast Training for Nonlinear Differential Equations

The Physics-Informed Stochastic Configuration Machine is proposed, a novel backpropagation-free framework for both forward and inverse problems in differential equations that achieves high-fidelity predictive accuracy and robust parameter identification while accelerating the training process by orders of magnitude compared to standard PINNs.

Physics-Informed Neural Networks for Fractional SEIR Models with Power Mittag-Leffler Kernels

SUC–PINNs: A physics-informed neural networks approach to inverse problems in epidemic models with partial observability

Experiments with synthetic data and COVID-19 surveillance data show that SUC–PINN recovers plausible hidden infection trajectories, yields stable parameter estimates, and provides accurate short-term forecasts, support SUC–PINN as a practical computational approach for inverse modeling and prediction in partially observed epidemic dynamics.

Failure-informed PINNs for a multi-strain SVEIR epidemic model

This paper pairing Failure-Informed PINNs with a Self-Adaptive Importance Sampling (SAIS) refinement strategy, and applying the combination to a nine-equation Susceptible/Vaccinated/Exposed/Infected/Recovered (SVEIR) model that follows three viral strains together with a vaccination compartment, shows an improvement of two to three orders of magnitude.