Bone mineral density, body composition, sex hormone levels, and insulin sensitivity in patients with Polyendocrine Metabolic Ovarian Syndrome.

Objective

To evaluate bone mineral density (BMD), body composition, sex hormone levels, and insulin sensitivity in women with Polyendocrine Metabolic Ovarian Syndrome (PMOS) and compare these parameters with those of women without the syndrome.

Methods

This cross-sectional study included 51 women with PMOS diagnosed according to the Rotterdam criteria and 30 women without the syndrome. Clinical characteristics, hormonal and metabolic profiles, body composition, and dual-energy X-ray absorptiometry-derived BMD were assessed. Women with PMOS were also stratified according to the presence or absence of insulin resistance.

Results

Women with PMOS exhibited significantly higher BMD at the total body, lumbar spine, femoral neck, and total hip than controls (all p < 0.05). Among women with PMOS, those with insulin resistance had higher femoral neck BMD than those without insulin resistance (1.124 vs. 0.950 g/cm2, p = 0.01). This association remained significant after adjustment for body mass index.

Conclusion

Women with PMOS had higher BMD across all evaluated skeletal sites than women without the syndrome. Within the PMOS group, insulin resistance was not independently associated with BMD after adjustment for body mass index, indicating that excess body weight may be a more important determinant of bone density than insulin resistance itself.Bone mass in PMOS: new insights into hyperandrogenism and hyperinsulinemia.