Open access
Celiac disease and developmental delay as the first manifestations of tripeptidyl peptidase 2 deficiency
Nursena Kologlu Ates
Dilan Demir Gumus
Ipek Ulkersoy
M. Aydin
O. Tin
Ecem Kahveci
N. Kepil
Esma Şengenç
J. Quinn
E. Yucel
A. Kıykım
O. Beser
Medicine
Abstract
shift toward a senescent B-cell profile may represent an important feature of the immune dysregulation observed in our patient. The combination of reduced functional B-cell subsets and underlying immune senescence likely explains the patient's susceptibility to recurrent otitis media and pneumonia despite complete dietary remission of celiac disease. In conclusion