Triangulating the Neuroprotective Mechanisms of Pterostilbene in Hyperhomocysteinemia Induced Cognitive Impairment: Insights from In Silico, Proteomics, and Experimental Validation

Limonin ameliorates hyperuricemia-induced cognitive impairment through modulation of microglial HIF-1α-driven neuroinflammation.

LIM ameliorates HUA-induced cognitive impairment by suppressing microglial activation and neuroinflammation, which is associated with the inhibition of the HIF-1α/iNOS signaling pathway, underscoring its therapeutic potential.

Lamotrigine Attenuates Lipopolysaccharide-Induced Working-Memory Impairment and Is Associated with Changes in Neuroinflammatory, Oxidative-Stress, and Apoptosis-Related Markers

Highlights What are the main findings? Lamotrigine (LTG) ameliorated lipopolysaccharide (LPS)-induced working-memory impairment and suppressed neuroinflammatory responses in the prefrontal cortex. LTG reduced oxidative stress and pro-apoptotic signaling while restoring endogenous antioxidant and anti-apoptotic defenses...

Ursolic acid attenuates LPS-induced cognitive dysfunction through the modulation of oxidative stress, neuroinflammation, and hippocampal synaptic plasticity.

BACKGROUND Neuroinflammation and oxidative stress play vital roles in the pathogenesis of neurodegenerative diseases characterized by cognitive decline. Ursolic acid (UA), a natural pentacyclic triterpenoid compound with reported anti-inflammatory and antioxidant properties, has been suggested as a potential neuroprote...

Postbiotics as a Therapeutic Target in Cognitive Impairment: Exploring into Molecular Pathways and Neuroprotective Effects.

A systematic evaluation of the role of postbiotics in the prevention and management of CI across different neurological and metabolic disorders is provided, and the available preclinical findings with potential therapeutic implications and future directions are summarized.

Neuroprotective potential of Prunetin in streptozotocin-induced cognitive dysfunction: insights from computational and experimental studies.

Trans-anethole attenuates streptozotocin-induced cognitive dysfunction by modulating oxidative stress and cholinergic activity

Cognitive impairment is a neurological disorder defined as an inability to learn, think, judge, remember, and make decisions. The primary cause of chronic, age- related cognitive decline is Alzheimer’s disease (AD), which is frequently studied as a representative model. The current therapies for AD provide only s...