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NUTRITIONAL AND THERAPEUTIC INTERVENTIONS IN THE TREATMENT OF METABOLIC SYNDROME

Fernando Malachias de Andrade Bergamo Campos Ferreira Yanne da Costa Alana Cássia Alencar Martins Sátira Larissa Daguer Pergher Borges Natália Passos Torres de Araújo Débora Profetisa Goncalves Melo Giulienny Maria Antunes Gonçalves V. Melo Jonas Marinho da Costa Natan Gomes de Oliveira Isadora Carvalho Segantini Marcelly Ottero de Oliveira Barreto S. S. de Medeiros M. G. B. de Santana Renata Cabredo Tohomazi

Aug 2026 · International Journal of Health Management Review · 0 citations

Abstract

Metabolic Syndrome (MetS) represents a global public health challenge associated with an elevated risk of type 2 diabetes mellitus and cardiovascular diseases. This study is a narrative literature review synthesizing recent evidence (2020–2025) regarding nutritional and therapeutic interventions for managing MetS, focusing on the PubMed database. The results highlight the Mediterranean Diet as the gold standard, demonstrating improvements in insulin sensitivity and lipid profiles. Innovative strategies, such as Time-Restricted Eating (TRE), show efficacy in reducing visceral fat and glycated hemoglobin, particularly when tailored to circadian rhythms. Modulation of the gut microbiota via polyphenols and fiber emerges as a key mechanism for mitigating meta-inflammation. Additionally, the study emphasizes the need for clinical differentiation between true subclinical hypothyroidism and adaptive responses to obesity, discouraging the use of levothyroxine for weight loss. It is concluded that MetS treatment requires a multidimensional, early, and personalized approach that integrates dietary quality, the timing of meals, and metabolic-endocrine balance.

DOI Semantic Scholar

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