This review aims to provide a comprehensive overview of the current molecular pathways and regulatory mechanisms underlying iron homeostasis and intracellular compartmentation in liver biology, emphasizing the roles of ferroptosis in several liver diseases.
Abstract
Ferroptosis is a form of non-apoptotic cell death driven by iron-dependent lipid peroxidation (LPO). Ferroptosis is closely associated with hepatic metabolic pathways, particularly those involving iron, fatty acids, amino acids, and redox changes. This review aims to provide a comprehensive overview of the current molecular pathways and regulatory mechanisms underlying iron homeostasis and intracellular compartmentation in liver biology, emphasizing the roles of ferroptosis in several liver diseases, such as ischemia-reperfusion injury, drug-induced liver injury, viral hepatitis, metabolic dysfunction–associated steatotic liver disease, alcohol-associated liver disease, fibrosis, and hepatocellular carcinoma. We have also discussed the challenges of interpreting ferroptosis-related data, proposed a framework for defining ferroptosis, and highlighted future research directions as well as the therapeutic potential of targeting ferroptosis in the treatment of various liver diseases.
Ferroptosis is a distinct form of regulated cell death driven by lipid peroxidation and redox imbalance. Since its formal recognition in 2012, ferroptosis has emerged as a central pathway linking metabolic stress and oxidative injury to both physiologic and pathologic processes. Its functions extend from tissue sculpti...
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Metabolic dysfunction-associated steatotic liver disease (MASLD) is a widespread chronic liver disease that can progress from steatosis to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Its pathogenesis involves lipotoxicity, iron metabolism disorders, and oxidative stress—the same three processes...
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This review systematically integrates the latest insights into the molecular mechanisms regulating ferroptosis, the pathophysiology of various intestinal diseases, and translational therapeutic strategies to provide a comprehensive roadmap for leveraging ferroptosis to manage intestinal diseases.
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Ferroptosis is a regulated form of iron-dependent cell death characterized by lipid peroxidation and oxidative stress. Increasing evidence indicates that ferroptosis plays an important role in gastrointestinal (GI) tumors, including esophageal, gastric, hepatic and colorectal cancer. Depending on the cellular context,...
This review summarizes current understanding of the molecular mechanisms governing cuproptosis and ferroptosis and identifies unresolved questions concerning pathway specificity, temporal regulation, biomarker validation, and the clinical safety of systemic or prolonged therapeutic modulation.
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Liver diseases involve major disturbances in iron metabolism, redox homeostasis, and lipid peroxidation; therefore, ferroptosis is considered as an important link between cellular stress and liver damage/progression. This article describes solute carrier family 7 member 11 (SLC7A11), the functional subunit of the cysti...
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