By decoupling clinical information retrieval from generative chitchat, LENOHA enhances safety, preserves privacy, and markedly reduces energy use, offering a practical blueprint for sustainable and equitable medical AI deployment across diverse care settings.
Abstract
Abstract Background Patients undergoing invasive procedures frequently experience anxiety and often have unanswered questions regarding the procedure. Although large language models show considerable promise for supporting patient communication in many cases, their deployment in health care is limited by the risk of hallucinations, data-privacy constraints, and high energy costs—factors that impede equitable access in resource-limited settings. Objective This study aims to develop and evaluate LENOHA (Low Energy, No Hallucination, Leave No One Behind Architecture), a locally executable dialog system for safe, equitable, and sustainable preprocedural communication. Methods We built expert-curated FAQ (frequently asked question) databases and independent test sets for 2 domains (tooth extraction and gastroscopy; 200 utterances per domain: 100 clinical questions and 100 casual). A sentence-transformer classifier routed inputs: clinical questions were answered verbatim from the vetted FAQs (nongenerative path), while casual conversation was handled by a locally hosted 8-billion-parameter small language model (Swallow-8B). We evaluated 4 sentence-transformer models (including E5-large-instruct) against cloud large language models (ChatGPT [GPT-4o] and Gemini Advanced) using accuracy, F1-score, and area under the receiver operating characteristic curve, and measured the on-device inference energy on a consumer graphics processing unit (RTX 3080). Results Across both domains (N=400), E5-large-instruct achieved an accuracy of 98.3% (393/400; 95% CI 96.4%‐99.1%) and an area under the curve of 0.996, with only 7 out of 400 (1.8%) misclassifications. This performance was not statistically different from that of ChatGPT (GPT-4o), which had 6 out of 400 (1.5%) errors (McNemar test with Holm adjustment; P>.99). Sustainability measurements showed approximately 2.23 mWh per request (latency≈0.10 s; video RAM≈2.2 GiB average, ≈2.5 GiB peak) for the nongenerative clinical path vs approximately 168.27 mWh (latency≈8.51 s; video RAM≈13.3 GiB average, ≈14.0 GiB peak) for small language model small talk—approximately a 75-fold higher energy footprint per reply for the generative path. Conclusions High-precision, nongenerative clinical support is feasible using local, low-cost hardware without cloud dependence. By decoupling clinical information retrieval from generative chitchat, LENOHA enhances safety, preserves privacy, and markedly reduces energy use, offering a practical blueprint for sustainable and equitable medical AI deployment across diverse care settings.
Developing artificial intelligence capable of clinical language comprehension and reliable diagnostic reasoning has remained a core challenge in biomedical engineering. While Large Language Models (LLMs) demonstrate significant potential in general natural language processing tasks, their direct application in the medical domain is severely constrained by parametric hallucinations and data silos. This paper introduces an end-to-end, resource-efficient, multilingual speech-driven Question-Answering (QA) framework optimized for localized clinical support. To accommodate deployment on consumer-grade execution environments, we implement Parameter-Efficient Fine-Tuning (PEFT) using Low-Rank Adaptation (LoRA) and 4-bit Quantized LoRA (QLoRA) configurations across open-source 3B and 7B parameter architectures. Human preference alignment is enforced via a stateful Reinforcement Learning with Human Feedback (RLHF) loop applying Proximal Policy Optimization (PPO). Crucially, to mitigate the vulnerabilities of passive information retrieval, we introduce an Active Validation Loop powered by Corrective Retrieval-Augmented Generation (CRAG). This validation engine is decoupled from the model harness using the Model Context Protocol (MCP), standardizing asynchronous lookups across dense vector repositories, clinical guidelines, and real-time electronic health registries.
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