Label-free spatial-frequency-shift (SFS) super-resolution imaging enables nanoscale visualization but fundamentally suffers from a severe trade-off between ultra-high resolution and high signal-to-noise ratio (SNR) when utilizing high-wavevector illumination. To overcome this limitation, recent advancements have introduced an enhanced deep spatial-frequency-shift (EDSFS) mechanism that engineers wavevector resonance with multilayered nanostructures. This approach selectively redistributes and amplifies high-spatial-frequency components, efficiently generating high-wavevector illumination while maintaining strong optical intensity. Consequently, the EDSFS mechanism mitigates the conventional resolution-SNR compromise, achieving sub-diffraction label-free imaging under visible light and significantly extending the coherent transfer function beyond 10/λ with robust fabrication tolerance. Ultimately, this shift from raw wavevector expansion toward the synergistic integration of engineered photonic structures and adaptive computational algorithms paves the way for high-throughput, application-oriented nanoscopic inspection.
Near-infrared (NIR) imaging is essential for biological and materials sensing, yet high-performance NIR detectors are often cost-prohibitive and plagued by high dark current. Nonlinear frequency upconversion offers a compelling solution by shifting NIR signals into the visible spectrum, allowing the use of mature silic...
Meng-Zi Yin, Hong Wang, Ming-Wen Zhang et al.· Applied Physics Letters· 0 citations
Super-resolution fluorescence microscopy overcomes the optical diffraction limit and has significantly advanced our understanding of biological complexity within the framework of fluorescence labelling1. Fluorescence labelling underpins this capability, enabling high photon budgets, superior signal contrast, and tuneab...
Quantitative phase microscopy (QPM) provides sensitive, label-free measurements of optical-path-length variations in transparent and weakly scattering specimens, offering valuable insights into biological structures without exogenous labels. However, its lateral resolution remains fundamentally constrained by optical d...
Yuan-Yuan Huang, Hao-Yu Li, Xiang-Yan Ding et al.· Journal of Physics: Photonic...· 0 citations
Interferometric scattering microscopy (iSCAT) enables label-free detection of nanoscale entities by interfering weak scattered light with a reference field, yielding high sensitivity for single-particle mass photometry, three-dimensional tracking, and kinetic studies of proteins, viruses, and nanoparticles—dynamics elu...
Sreyash Sarkar, Yue Xu, Laurence W. Fitzpatrick et al.· Enhanced Spectroscopies and...· 0 citations
An electrically modulated dual-focus metalens-based photoacoustic microscopy (meta-PAM) system designed to enhance axial coverage while preserving high lateral resolution in three-dimensional imaging is presented, demonstrating its effectiveness by imaging a chemically induced corneal burn in rat eyes.
Hongyoon Kim, Eunwoo Park, Jeongwoo Park et al.· Light: Science & Application...· 0 citations
The mid-wave infrared (MWIR, 3-5 microns) is indispensable for thermal sensing, gas detection, long-range imaging, and free-space optical communications. Meta-optics offer a compact, lightweight, and potentially low-cost alternative to conventional refractive optics, making them attractive for size, weight, and power (...
Rose Johnson, Debabrata Mandal, Zi-Hao Zou et al.· 0 citations
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