Open access
Baloxavir-Based Combination Therapy for Protection against Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Mice
S. Min
Ju Ryeong Lee
Beom Kyu Kim
Ji-Hyun Park
Dong Gyu Lee
Gi-Chan Lee
Se-Hee An
Santosh Chokkakula
Aman Jain
Young K. Choi
Y. Baek
Min-Suk Song
Medicine
Abstract
Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus continues to cause animal outbreaks and sporadic zoonotic infections. In a mouse model of lethal influenza disease, we compared oseltamivir, baloxavir, and molnupiravir monotherapies with 2-drug combinations. Baloxavir-based combinations improved survival, reduced lung viral loads, and prevented extrapulmonary dissemination, supporting H5N1 preparedness strategies.