Dysregulated mRNA Translation in Alzheimer’s Disease: Mechanisms, Therapeutic Opportunities, and Challenges for Clinical Translation

Abstract

: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and a growing public health concern. Its core pathological features include cerebral amyloid-β deposition and tau aggregation. mRNA translation is a tightly regulated process essential for gene expression and protein synthesis. It plays critical roles in neural development, synaptogenesis