Skip to content
Review

Microplastics and nanoplastics in human toxicity: ROS-mediated mechanisms, cellular damage and systemic effects

Aug 2026 · Molecular Biology Reports · Vol 53 · 3 citations · 162 references
Medicine

TL;DR

Current understanding of the sources, cellular uptake, ROS-mediated mechanisms, and multi-organ toxicological effects of MPs and NPs is consolidated.

View source

Similar papers

Review Open access Oct 2026

Resveratrol in Microplastic- and Nanoplastic-Induced Toxicity: Current Evidence, Mechanistic Insights, and Future Directions.

Microplastic (MP; MPs) and nanoplastic (NP; NPs) pollution poses a growing threat to global health. Their small size and large surface area facilitate ingestion, accumulation, and interactions with biological systems, leading to toxicity through oxidative stress, inflammation, mitochondrial dysfunction, and cell death....

S. Sepahi, H. Mashayekhi-sardoo, Adel Ghorani Azam et al. · 0 citations
Review Open access Sep 2026

Micro- and Nanoplastics in the Human Exposome: Environmental Pathways, Kidney Toxicity, and Implications for Public Health Risk Assessment

Current evidence regarding environmental exposure pathways, biodistribution, and molecular mechanisms of MNP-induced toxicity are integrated, emphasizing the need for integrated exposome-based approaches, omics technologies, advanced experimental models, and longitudinal studies to improve human health risk assessment...

Mariana Abrantes Do Amaral, O. Foresto-Neto, M. D. de Oliveira et al. · 0 citations
Open access Aug 2026

Nanoplastic Particle Exposure Induces Toxicity and Amplifies Cellular Stress in THP‐1 Macrophages: Insights on Molecular Pathways and Circulating Proteome Interaction

ABSTRACT The widespread accumulation of polystyrene nanoplastic particles (NPPs) in the environment has raised significant human health concerns, specifically on immune function. However, the underlying molecular mechanisms behind NPP induced immune cell (monocyte/macrophage) toxicity and their relationship with existi...

Balamurali Mahalakshmi, Gobichettipalayam Balasubramaniam Maadurshni, Thittumpuram Manikandan Anjana et al. · 0 citations
Review Open access Oct 2026

Microplastics and nanoplastics as potential ecological oncogenic co-drivers: rewiring host–microbe interactions in cancer

A hypothesis-generating mechanistic framework in which MPs/NPs may influence cancer-related processes through the integration of environmental exposure, epithelial barrier disruption, immune dysregulation, and tumor microenvironment remodeling is proposed.

Richard Ponce-Cusi, C. Barletta-Carrillo, Nesstor Pilco-Ferreto · 0 citations
Review Open access Oct 2026

Microplastics and the Kidney: A Narrative Review of Human Evidence, Molecular Mechanisms of Cell Injury, and Future Directions

Overall, available evidence provides a mechanistic basis for MP-induced kidney injury, but its clinical relevance and contribution to human kidney disease remain to be established.

E. La Porta, Micaela Gentile, Marco Quaglia et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.