Microplastic (MP; MPs) and nanoplastic (NP; NPs) pollution poses a growing threat to global health. Their small size and large surface area facilitate ingestion, accumulation, and interactions with biological systems, leading to toxicity through oxidative stress, inflammation, mitochondrial dysfunction, and cell death....
S. Sepahi, H. Mashayekhi-sardoo, Adel Ghorani Azam et al.· Molecular Nutrition & Food R...· 0 citations
The need for integrated and interdisciplinary research to better understand microplastic-associated carcinogenesis is emphasized to support effective risk assessment and regulatory strategies.
Current evidence regarding environmental exposure pathways, biodistribution, and molecular mechanisms of MNP-induced toxicity are integrated, emphasizing the need for integrated exposome-based approaches, omics technologies, advanced experimental models, and longitudinal studies to improve human health risk assessment...
Mariana Abrantes Do Amaral, O. Foresto-Neto, M. D. de Oliveira et al.· International Journal of Mol...· 0 citations
ABSTRACT The widespread accumulation of polystyrene nanoplastic particles (NPPs) in the environment has raised significant human health concerns, specifically on immune function. However, the underlying molecular mechanisms behind NPP induced immune cell (monocyte/macrophage) toxicity and their relationship with existi...
Balamurali Mahalakshmi, Gobichettipalayam Balasubramaniam Maadurshni, Thittumpuram Manikandan Anjana et al.· Journal of biochemical and m...· 0 citations
A hypothesis-generating mechanistic framework in which MPs/NPs may influence cancer-related processes through the integration of environmental exposure, epithelial barrier disruption, immune dysregulation, and tumor microenvironment remodeling is proposed.
Richard Ponce-Cusi, C. Barletta-Carrillo, Nesstor Pilco-Ferreto· Frontiers in Cellular and In...· 0 citations
Overall, available evidence provides a mechanistic basis for MP-induced kidney injury, but its clinical relevance and contribution to human kidney disease remain to be established.
E. La Porta, Micaela Gentile, Marco Quaglia et al.· International Journal of Mol...· 0 citations
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