The pathology of PSP causes clinically relevant changes in neural temporal dynamics, leading to a greater proportion of time in inefficient brain-states, leading to a greater proportion of time in networks associated with higher cognitive functions.
Temporal features of brain network dynamics may provide candidate imaging markers for distinguishing PD and PSP while offering mechanistic insights into non‐motor symptomatology, however, their diagnostic applicability requires validation in independent external multicenter cohorts.
Chen-Fei Ye, Jia-Hui Shi, Ji-Liang Fang et al.· CNS Neuroscience & Therapeut...· 0 citations
Dopaminergic depletion is associated with a targeted SMN reorganization, potentially maintaining network information flow despite progressive hub loss, and whether this reorganization represents compensation or a consequence of progressive pathology requires further longitudinal assessment.
Adrian L. Asendorf, Verena Dzialas, T. van Eimeren et al.· Movement Disorders· 0 citations
These network-specific, hemisphere-sensitive measures may serve as biomarkers for diagnosis, tracking, and prognosis of cognitive decline, and could inform personalized network-targeted neuromodulation in AD.
G. Bertazzoli, E. Canu, C. Bagattini et al.· Alzheimer's Research & T...· 0 citations
Parkinson's disease (PD) and multiple system atrophy (MSA) are alpha-synuclein-related neurodegenerative disorders with overlapping motor and non-motor symptoms but distinct pathology, clinical management, and prognosis. Early differential diagnosis, particularly between PD and the parkinsonian subtype of MSA (MSA-P),...
Dai-Chao Chen, Hua-Da Tang, Yan-Fei Pan et al.· NeuroImage: Clinical· 0 citations
BACKGROUND AND OBJECTIVES
Small fiber pathology is an intrinsic feature of Parkinson disease (PD), yet its relevance to central neurodegeneration remains unclear. Given that cognitive impairment is a major manifestation of disease progression closely linked to cortical structural changes, we aimed to determine whether...
Ming-Lei Liu, Tian-Yuan Yang, Lan-Jun Li et al.· Neurology· 0 citations
It is suggested that PD is characterized by extensive disruption of cortical-cerebellar functional hierarchy, exceeding the relatively limited alterations observed in ET.
Qiang Liu, Ze-Zhong Zheng, Mo-Xuan Zhang et al.· Frontiers in Neurology· 0 citations
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