Oct 2026· Journal of Pediatric Advance Research· Vol 5, pp. 1-8· 0 citations· 17 references
TL;DR
The future of male pediatric fertility preservation is poised for transformative progress and emerging techniques such as testicular tissue cryopreservation, in-vitro spermatogenesis and stem cell-based therapies offer hope for restoring reproductive potential in boys who otherwise face irreversible infertility.
Abstract
The future of male pediatric fertility preservation is poised for transformative progress. Over the past fifteen years, the world has witnessed a notable decline in birth rates, a phenomenon often referred to as global low fertility or denatality. While social and economic determinants play a significant role, biological factors, particularly male infertility, have emerged as an increasingly recognized contributor to declining birth rates. Male infertility affects approximately 7-12% of men globally and is implicated in nearly 40-50% of all couples experiencing difficulties in conceiving. For this reason the role of pediatric andrology is essential to reduce adult male infertility. Emerging techniques such as testicular tissue cryopreservation, in-vitro spermatogenesis and stem cell-based therapies offer hope for restoring reproductive potential in boys who otherwise face irreversible infertility. Achieving this potential will require a combination of scientific innovation, ethical guidance and clinical integration.
Current knowledge regarding fertility preservation (FP) in girls is derived predominantly from pediatric oncology cohorts; however, FP is increasingly being applied to non-oncological conditions associated with impaired fertility, including differences of sex development (DSD). Turner syndrome (TS), characterized by ac...
Z. Kolesinska, M. Obara-Moszyńska, Marek Niedziela et al.· Frontiers in Endocrinology· 0 citations
BACKGROUND
Men attending ART clinics often have poor fertility awareness and are typically overlooked for psychological support. Recent developments in understanding the link between sub-fertility, healthspan and lifespan enforce the need for comprehensive health assessments of men attending ART clinics. Evidence now s...
Georgia A. Bennett, Shannon P. Smyth, D. Gardner et al.· Human Reproduction Update· 0 citations
Background: Infertility is increasingly recognized as a significant global public health concern. A thorough understanding of the diverse causes of infertility and their influence on treatment outcomes is essential for optimizing therapeutic strategies and improving success rates. Methods: In this study, we analyzed da...
Hale Bayram, Y. D. Cakil, Belgin Selam et al.· Journal of Clinical Medicine· 0 citations
Now a days more and more couples are showing up at fertility clinics around the world, searching for answers, hope and eventual parenthood. Despite the enormous growth in population it should be noted that humans are not very efficient at producing babies. Infertility is a significant global health concern affecting ap...
Dr Shaikh Ayesha Bashir and Dr. Vasanthi Thaondamb· International Journal of Adv...· 0 citations
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