Progress on chitosan potential for wound healing

Abstract

Chitosan is increasingly effective in biomedical applications, especially as a wound-healing material. The above-mentioned effectiveness is due to its interesting biological properties and effect on human tissues. In wound healing, chitosan initiates recovery during the haemostasis stage, primarily through charge-mediated blood coagulation. Advancement to the next stages (such as the inflammatory, proliferative, and remodelling phases) depends solely on the successful and timely process of blood coagulation. Chitosan materials, such as films, nanofibers, and sponges, are expanding their applications in wound healing. Chitosan wound dressings were used to promote blood coagulation. They also led to support for the reduction of pro-inflammatory cytokine levels. Chitosan wound dressings were also effective in the proliferation and remodelling phase. In short, the objective of this study was to probe the potential of chitosan materials in terms of their use for wound healing over the past few years.