Comparative insights into miRNA-mediated repair across nervous system injuries: Implications for histology and regenerative medicine.

Review Oct 2026

Neurorepair in Spinal Cord Injury: Convergent MicroRNA-Mediated Pathways Drive Astrocyte Pathology and Their Relevance to Human Biomarker Development.

Spinal cord injury (SCI) initiates a complex secondary injury cascade characterized by neuroinflammation, astrocyte reactivity, neuronal loss, and glial scar formation, all of which influence endogenous repair and functional recovery. Emerging evidence identifies microRNAs (miRNAs) as post-transcriptional regulators of...

Mehek Sharma, He-Dong Li · Journal of Neurotrauma · 0 citations

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Review Open access Sep 2026

Multicellular Exosomes as Therapeutic Modulators of Neuroinflammation: Mechanisms and Clinical Prospects

Abstract Neuroinflammation is a fundamental pathological driver of diverse central nervous system (CNS) disorders, including Alzheimer’s disease, stroke, and traumatic brain injury. This complex process is characterized by persistent neuronal damage and the orchestrated response of glial and peripheral immune cells. In...

Jia-You Qiu, Ming-Bo Fan, Cheng-Hu Wu · International Journal of Nan... · 0 citations

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Review Open access Aug 2026

Tissue repair in the central nervous system: the epigenetic programming of regulatory T cells

Regulatory T cells are well known for their immunomodulatory role but also their regenerative function is increasingly recognized across multiple tissue types including skeletal muscle, lung and the central nervous system (CNS). In the CNS, Tregs have been shown to promote oligodendrocyte precursor cell differentiation...

Sarah Chenine, A. Tiane, P. Baeten et al. · Frontiers in Immunology · 0 citations

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Review Oct 2026

Aging, Regeneration, and Peripheral Nerve Repair: Integrated Multi-Omics Biomarkers and AI-Enabled Therapeutic Discovery Approaches.

Peripheral nerve injury (PNI) remains a major cause of long-term sensory and motor dysfunction, imposing a substantial clinical and socioeconomic burden worldwide. Although peripheral nerves possess intrinsic regenerative capacity, functional recovery is often incomplete because of the complex interplay among axonal de...

Muhanad Alhujaily, A. Ashour, A. Shafie et al. · Ageing Research Reviews · 0 citations

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Review Open access Sep 2026

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

This review summarizes recent advances in microglial biology across acute brain injury, neurodegenerative and demyelinating disorders, central nervous system infections, and psychiatric and neurodevelopmental diseases and provides new opportunities for precision therapy.

Jie Chen, Wangzheqi Zhang, Li-Zhou Song et al. · Clinical and Translational M... · 0 citations

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Review Open access Oct 2026

Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives

Peripheral nerve injury (PNI) affects 13–23 individuals per 100,000 annually, and functional recovery hinges on faithful remyelination of regenerating axons by Schwann cells (SCs). This review integrates the complete molecular logic governing the transition from injury‐induced SC plasticity to mature myelin regeneratio...

Li-Xin Huang, Tao Sun, Yi-Bo Zhao et al. · MedComm · 0 citations

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