Statin Therapy for Cardiovascular Disease Prevention in People Living with Human Immunodeficiency Virus: A Systematic Review of Efficacy, Safety, and Clinical Challenges
Clinically, pitavastatin reduced serious cardiovascular events by 35% compared to placebo in a trial of >7,700 PLWH aged ≥40 years on ART, supporting its broader preventive use.
Current understanding of atherosclerosis pathogenesis in individuals with HIV is reviewed, focusing on recent findings from the REPRIEVE trial, and current approaches to improving cardiovascular risk assessment across clinical, biological, and computational levels are outlined.
INTRODUCTION
Dialysis patients with established atherosclerotic cardiovascular disease (ASCVD) face exceptionally high risks of mortality and recurrent cardiovascular events, yet remain substantially underrepresented in major statin trials. We aimed to synthesize evidence from studies restricted to this population to e...
K. Chienwichai, Pannawat Mongkolrattanakul, Arunchai Chang et al.· Kidney & Blood Pressure Rese...· 0 citations
Background Statins remain the cornerstone of pharmacological prevention for atherosclerotic cardiovascular disease (ASCVD) because of their proven ability to reduce low-density lipoprotein cholesterol (LDL-C) and major adverse cardiovascular events (MACE). However, many patients continue to experience ASCVD events desp...
Muhammad Abdul Rehman, M. O. Oduoye, D. J. Ozoemena et al.· Frontiers in Cardiovascular...· 0 citations
High levels of blood cholesterol are a major risk factor for atherosclerotic cardiovascular disease and require early and consistent utilization of statins as first-line medications to avoid disabling or even deadly consequences. Nevertheless, real-world treatment adherence is significantly lower than that reported in...
F. Strollo, G. Guarino, Ersilia Satta et al.· Diabetes Therapy· 0 citations
ABSTRACT Background Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality, and many high‐risk patients fail to reach LDL‐cholesterol (LDL‐C) targets on statins alone. Evolocumab, a PCSK9 inhibitor, offers potent LDL‐C lowering, but a synthesis of its lipid and clinical benefits in seconda...
Anika Goel, M. Naveed, H. Tandel et al.· Endocrinology, Diabetes & Me...· 0 citations
ABSTRACT Introduction Dyslipidaemia remains a major contributor to atherosclerotic cardiovascular disease (ASCVD), and many patients fail to achieve recommended low‐density lipoprotein cholesterol (LDL‐C) targets despite statin therapy or are unable to tolerate statins. Oral non‐statin therapies have emerged as importa...
Tamer Hodrob, Reem J. Saad, Aya Hamdy et al.· Endocrinology, Diabetes & Me...· 0 citations
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