Novel imaging methods that may extend 2D spatial analyses into 3D modelling, and the complementary applicability of deep-learning-based computational pathology are discussed, as well as the advantages, limitations and applications of spatial omics technologies in kidney research.
Heterogeneous tumor microenvironment (TME) in lung cancer plays a crucial role in disease progression and resistance to therapy. Despite advances in single-cell and bulk omics profiling, these methods often overlook spatial context, which is vital for understanding cell-cell interactions and regional heterogeneity. In...
Sanjukta Dasgupta, Subhayan Das, Shouvik Saha· Current Problems in Cancer· 0 citations
Recent technological advances and applications of multi-omics in kidney diseases are critically reviewed, with particular attention to biomarker discovery and clinical translation, and the challenges and future directions of multi-omics integration and its application in precision medicine are discussed.
This review discusses how spatial transcriptomics and proteomics enable extraction of spatial metrics including cell density, proximity, and community-level organization and highlights critical spatial features, including immune cell infiltration patterns and vascular niches that are strongly linked to patient outcomes...
Xia Lei, Xuan Cui, Y. Ni et al.· Journal of Advanced Research· 0 citations
VirTues-derived biomarkers predict anti-PD-L1 chemo-immunotherapy response and stratify disease-free survival in an independent cohort, outperforming state-of-the-art biomarkers derived from the same datasets and current clinical stratification schemes.
Johann Wenckstern, Eeshaan Jain, Benedikt von Querfurth et al.· Nature· 4 citations
A post-spatial profiling workflow that combines the Xenium platform with iterative indirect immunofluorescence imaging (4i) on formalin-fixed paraffin-embedded (FFPE) human brain tissue to capture key pathological features for Alzheimer’s disease (AD) and facilitate cell segmentation is reported.
Berke Karaahmet, Tsering D. Lama, An-Qi Wang et al.· bioRxiv· 0 citations
This review highlights emerging evidence from spatial profiling studies demonstrating that PDAC and its precursor lesions are not just a simple mixture of malignant and stromal cells but rather a structured ecosystem with spatially distinct immune and fibroblast niches.
S. Bae, A. Tsirigos, Ji-Min Min et al.· Experimental and Molecular M...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
