Sep 2026· Handbook of Experimental Pharmacology· 0 citations
Medicine
TL;DR
Advances being made in the field of boron medicinal chemistry in terms of boron-containing peptides and sugars are discussed, including FDA-approved drugs, chemical biology imaging tools, preclinical compounds, and boron neutron capture therapy (BNCT) delivery agents.
Boronic acids are invaluable chemical reagents that enable the synthesis of complex organic molecules and are uniquely leveraged by medicinal chemists to target biological nucleophiles via an electrophilic boron center, thereby functioning as reversible covalent inhibitors. Despite their prevalence, boronic acids remai...
Forrest G. FitzGerald, Jasmin M. Frei, Erika Zhang et al.· RSC Chemical Biology· 0 citations
Overall, boron‐based bioisosteres represent a versatile platform for developing new therapeutics across diverse disease areas, including antifungal drugs such as tavaborole and crisaborole, as well as late‐stage candidates like epetraborole and acoziborole.
Martin Behringer, J. Kühn, F. Meyer-Almes· ChemMedChem· 0 citations
Macrocyclic scaffolds have become increasingly important in modern drug discovery owing to their structural preorganization, favorable pharmacological properties, and widespread incorporation into peptide- and amino acid-based therapeutics. In contrast, the integration of biologically relevant amino acid architectures...
Justin C. Holmes, Ballard C. Smith, Oluwatosin A. Obisesan et al.· Journal of Inorganic Biochem...· 0 citations
This review summarizes recent synthetic strategies, pharmacological activities, structure-activity relationships, and biosynthetic and mechanistic insights highlighting the significance of oxazole motifs in modern drug discovery.
J. Sharma, Sushil Kumar· Mini-Reviews in Medical Chem...· 0 citations
This review covers current breakthroughs in sulfonamide derivative production, biological activity, resistance mechanisms, and therapeutics and nanotechnology, AI-assisted drug discovery, and multitarget therapy design which increase sulfonamide-based treatment selectivity and efficacy.
Dina Saleem, Hawazin Aziz Hamim, Sura S. Raoof· South Asian Research Journal...· 0 citations
Boron neutron capture therapy (BNCT) offers a highly selective approach to cancer treatment, its efficacy critically dependent on the design and delivery of boron-rich agents. Among the most promising candidates are unnatural boronated amino acids, which exploit endogenous amino acid transporters to achieve preferentia...
G. Kabalka, Reema R. Batra, D. Hingane et al.· Bioorganic chemistry (Print)· 0 citations
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