Aug 2026· Klinicka onkologie· Vol 39 Supplementum 1, pp.
46-48
· 0 citations
Medicine
TL;DR
Systematically mapping biomarkers of exposure to each hallmark of cancer could provide a powerful strategy to identify modifiable risk factors with translational relevance and generate mechanistic insights to advance precision cancer prevention.
Abstract
Cancer risk is predominantly shaped by environmental exposures interacting with genetic susceptibility, yet modifiable non-genetic determinants remain insufficiently characterised. The human exposome framework promotes a comprehensive, life-course approach to studying chemical, biological, and physical exposures alongside socioeconomic and psychosocial factors, but it is underutilised in cancer research. Systematically mapping biomarkers of exposure to each hallmark of cancer could provide a powerful strategy to identify modifiable risk factors with translational relevance. Czechia, with its pronounced geographic variation in cancer incidence and strong research infrastructure, provides an ideal setting to pioneer such "functional exposomics" approaches. Integrating these methods into cancer research could help identify actionable environmental drivers and generate mechanistic insights to advance precision cancer prevention.
Persistent racial disparities in breast cancer outcomes, including higher prevalence of aggressive and treatment-resistant tumor subtypes, have led to increased mortality among African-American compared with White women. Environmental contaminants and psychosocial stressors have emerged as co-occurring exposures...
Sabrina S. Chow, Lauren E. McCullough, M. Maliniak et al.· Cancer Epidemiology, Biomark...· 0 citations
Breast cancer is a heterogeneous disease driven by complex interactions between genetic, hormonal, metabolic, lifestyle, and environmental factors. Among environmental exposures, agricultural pesticides represent potential contributors to breast carcinogenesis through endocrine-disrupting, oxidative, genotoxic, and epi...
Emine Tasan, Giuseppina Augimeri, D. Bonofiglio et al.· Journal of Xenobiotics· 0 citations
Nearly 38% of cancer cases worldwide are attributable to modifiable risk factors. Emerging evidences suggest that nutrient-sensitive regulatory networks serve as molecular intermediaries connecting the exposome to cancer hallmark acquisition. Epigenetic plasticity positions diet as a modifiable determinant of cancer su...
Chang Gu, Xin Shi, Bo-Lin Xing et al.· The Innovation Nutrition· 0 citations
Exposomics provides a systems‐level framework to characterize the environmental exposures experienced across the life course and their biological consequences, offering critical insights into tumor initiation and precision prevention. Advances in sensing technologies, intelligent materials, and data science now enable...
Kaicheng Shen, Wei-Yi Wang, Yang Wang et al.· Advancement of science· 0 citations
Background: Environmental exposures and biological susceptibility contribute to the complexity in cancer vulnerability, particularly in settings where comprehensive environmental monitoring and longitudinal exposure data are limited. Scenario-based modeling can provide a structured approach for exploring potential envi...
Because genetics and the environment interact to drive gene expression, we propose that exposomics must now be incorporated into the multi-omics paradigm to complete the overall biological pathway. Exposomics' groundbreaking tools and life-course framework holistically characterize non-genetic (environment) components...
K. Makris, A. Baccarelli, E. K. Silverman et al.· Zbornik radova· 0 citations
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