Evidence is synthesized that ER stress is not merely a correlation of aging but a mechanistic contributor to age-related decline, with senescence emerging as a major downstream fate in multiple tissues and therapeutic opportunities and open questions centered on restoring adaptive PERK/ISR dynamics to support healthy aging are discussed.
This review synthesizes current research on how intracellular C3 (intC3), and intracellular C5 (intC5) in certain contexts engage in extensive crosstalk with the mTOR, NF-κB, and AMPK pathways to modulate core cellular processes to modulate age-related diseases.
Naheemat Modupeola Gold, M. N. Okeke, Samuel Ewhea Ajoronor et al.· Ageing Research Reviews· 0 citations
This synthesis provides a framework for understanding how SUMOylation links metabolic stress to tissue-specific aging trajectories and therapeutic potential and evaluates emerging translational approaches that highlight both the opportunities and challenges of targeting SUMO-regulated stress responses in aging.
Xin-Yue Liu, Shuang Chen, Dong-Can Liu et al.· Ageing Research Reviews· 0 citations
Investigation of how neuronal ERO1L elevation reshapes cellular homeostasis before overt dysfunction in Drosophila melanogaster establishes a pre-symptomatic state in which proteostatic and metabolic adaptation coexists with early vulnerability of nuclear and RNA-homeostasis pathways, preceding overt oxidative stress a...
L. Lo Piccolo, Ranchana Yeewa, Puttachat Poound et al.· bioRxiv· 0 citations
Overall, aging outcomes reflect a dynamic equilibrium between damage and repair processes, and how this balance is modulated in long-lived individuals may inform strategies to promote healthy aging and delay the onset of age-related diseases.
S. Sideri, M. Cosentino, Laura Forcina et al.· Mechanisms of Ageing and Dev...· 0 citations
This review discusses the multifaceted roles of senescence along the liver disease trajectory, from its early protective functions in tissue repair to its later pathologic contributions to chronic liver disease and tumor progression, underscoring how cell type, stage of senescence program, disease stage and microenviro...
Efi Tsouri, Niovi Athanasopoulou, L. Akkari et al.· Seminars in Immunology· 0 citations
How cells balance this tightrope between adaptation and cell death in the context of cancer is dissected, and how UPR signaling drives angiogenesis, metastasis, immune-evasion, and chemoresistance is explored before finally discussing its therapeutic potential.
