The role of the UPS in glial cells in various neurodegenerative diseases is reviewed, and how studying glial cell function might provide essential information in unraveling mechanisms of neurodegenerative diseases is discussed.
Dysregulation of ALP-associated processes, including autophagic flux, chaperone-mediated autophagy, endolysosomal trafficking, lysosomal pH and ion balance, and lysosomal metabolic signaling, is implicated in both the pathogenesis and progression of neurodegenerative diseases, with an emphasis on Alzheimer’s disease an...
Samantha R. McDonough, Aditya K. Rao, Jacqueline M. McAleer et al.· Molecular Neurodegeneration...· 0 citations
The biogenesis, classification, isolation methods, and molecular content of EVs are reviewed, and their role in the pathogenesis, diagnosis, and treatment of the most important neurodegenerative diseases is analyzed.
S. Mohammad, A. Vasudevan, G. Oriquat et al.· Behavioural Brain Research· 0 citations
Restoration of microglial lysosomal acidification represents a promising therapeutic strategy for neurodegenerative diseases and a prognostic biomarker for disease progression and therapeutic response.
R. Jaganathan, Srilakshmi Vijayakumar, Yinchi Chen et al.· Neurobiology of Disease· 0 citations
Alzheimer's disease (AD) is a progressively debilitating neurodegenerative condition characterized by the accumulation of amyloid-β (Aβ), tau pathology, synaptopathy, and neuron loss. Recent studies suggest that Neuroinflammation is a critical part of the disease process rather than an accompanying feature of the menti...
Almas Meheboob Pathan· International Journal of The...· 0 citations
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