MATR3 promotes proliferation and invasion of colon adenocarcinoma cells: bulk, single-cell transcriptomic analysis and experimental validation

Abstract

Highlights • MATR3 is significantly upregulated in colorectal cancer tissues and is associated with poor prognosis in patients.• Knocking out MATR3 significantly inhibits the proliferation, migration, and invasion ability of colorectal cancer cells.• Animal experiments have confirmed that knocking out MATR3 can significantly inhibit tumor growth in vivo.