APG emerges as a promising supplementary compound for hypertension management, combining vascular, molecular, and microbiome-mediated mechanisms with a strong safety margin.
Diabetes mellitus (DM), a chronic metabolic disorder characterized by persistent hyperglycemia, poses a significant global health burden. Berberine (BBR), a natural isoquinoline alkaloid derived from medicinal plants such as Coptidis Rhizoma, has shown therapeutic promise for DM and its complications. Preclinical and c...
Yi-Le Liao, Yu Gui, Tong-Yi Li et al.· The American Journal of Chin...· 0 citations
Cannabinoid signaling has attracted increasing interest in diabetes because the endocannabinoid system regulates energy balance, glucose and lipid metabolism, inflammation, and tissue homeostasis. However, its therapeutic relevance remains uncertain. This study combined scientometric mapping with a critical synthesis o...
Isabella de Fátima Ramos de Almeida, Andressa Zago, Ariane Krause Padilha Lorenzett et al.· Future Pharmacology· 0 citations
Curcumin, the major curcuminoid of turmeric (Curcuma longa L.), has attracted sustained interest as a nutraceutical with pleiotropic anti-inflammatory, antioxidant, and vascular actions. However, extrapolating experimental in vitro findings to cardiovascular outcomes in humans is challenged by low aqueous solubility, c...
Katarzyna Zolnik, A. Mogielnicki, B. Kalaska· Frontiers in Pharmacology· 0 citations
This review aimed to critically synthesize current evidence on the role of coumarins in hypertension management, integrating mechanistic insights, preclinical findings, pharmacokinetic considerations, and available clinical data.
This review systematically examines the mechanisms of major PDBIs in hypertension, focusing on their regulation of vascular function, renin-angiotensin-aldosterone system and sympathetic nervous system, water-salt homeostasis, and target organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan et al.· Phytotherapy Research· 1 citation
Hyperlipidaemia is a major modifiable risk factor for cardiovascular disease and remains a global health concern. Although conventional lipid-lowering drugs are effective, their long-term use is often associated with adverse effects, prompting interest in safer dietary alternatives. Flavonoids, such as quercetin, narin...
Shankul Kumar, A. Patel, Vedant Kumar Prajapati et al.· Current pharmaceutical desig...· 0 citations
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