Among the staging systems assessed, CORSS remained independently associated with OS and appeared to provide complementary prognostic information beyond rTNM, although formal comparative measures of discrimination and calibration were not performed.
Abstract
Simple Summary Oral squamous cell carcinoma (OSCC) frequently recurs even in patients with early-stage disease. When recurrence occurs, salvage surgery often represents the only potentially curative treatment; however, predicting patient outcomes remains challenging. In this study, we analyzed 49 consecutive patients with recurrent OSCC who underwent salvage surgery at our institution. Clinical, pathological, and recurrence-related factors were evaluated, and different staging systems were compared in terms of their ability to predict prognosis. Although several variables were associated with poorer survival in univariate analysis, only close or positive surgical margins and lymph node involvement were identified as independent adverse prognostic factors in multivariable analysis. Among the staging systems assessed, CORSS remained independently associated with OS and appeared to provide complementary prognostic information beyond rTNM, although formal comparative measures of discrimination and calibration were not performed.
BACKGROUND
Recurrence in oral cavity (OC) and oropharyngeal (OP) squamous cell carcinoma (SCC) remains common, with poor long-term survival despite advances in systemic therapy. While surgical salvage has historically conferred a survival advantage, the emergence of immunotherapy has prompted re-evaluation of optimal s...
Isaac Solomon, Joshua Lee, Tammy B. Pham et al.· Oral Oncology· 0 citations
Simple Summary Oesophageal squamous cell carcinoma is a common and aggressive cancer with a high risk of recurrence after surgery. New treatments combining immunotherapy and chemotherapy before surgery have improved outcomes for some patients, but it remains unclear how to identify those who are most likely to benefit....
OBJECTIVE
Lymphovascular invasion (LVI) is routinely reported in laryngeal squamous cell carcinoma (LSCC), yet its independent prognostic significance and therapeutic implications remain uncertain. We evaluated the association between LVI and overall survival (OS) in a large cohort of surgically treated LSCC.
METHODS...
F. Porto-Gutierrez, Alexa J. Kacin, Brett Campbell et al.· The Laryngoscope· 0 citations
BACKGROUND
Perineural invasion (PNI) is an established adverse prognostic factor in oral squamous cell carcinoma (OSCC), but the implications of its extent as well as its relationship with surgical margin status and the extent of microscopic tumor spread remain unclear.
METHODS
We retrospectively analyzed 165 patient...
Michael A. Müller, Muriel D. Brada, Niels J. Rupp et al.· Head and Neck· 0 citations
Surgical margin status, perineural invasion and nodal stage were consistent, independent determinants of prognosis that identify high-risk patients; clear margins and accurate nodal assessment should be prioritised, though the retrospective design precludes causal inference.
Mustafa Aktaş, Senem Çengel Kurnaz, Emre Demirel et al.· European archives of oto-rhi...· 0 citations
Objective: Definitive chemoradiotherapy (CRT) is an established organ-preservation strategy for laryngeal squamous cell carcinoma (LSCC). However, real-world data regarding long-term survival and prognostic factors remain limited. This study evaluated survival outcomes, prognostic factors in LSCC patients treated with...
Asma Daneshvar, C. Abakay, Meral Kurt et al.· Radiation Sciences in Oncolo...· 0 citations
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