2026· International Conference on Conceptual Structures· pp. 159-171· 0 citations· 26 references
Computer Science
TL;DR
These findings support network curvature as a general, domain-independent indicator of biological network dysfunction, highlighting its potential to reveal fundamental geometric signatures of disease that are not captured by conventional connectivity measures.
By decoupling directed regulatory flows from systemic confounding, this macroscopic algebraic approach challenges universal treatment protocols, highlighting the necessity for sex-specific precision interventions in managing obesity-driven cardiometabolic risk.
Jia-Peng Wang, Yu Wang, Xin Tang et al.· Computers in Biology and Med...· 0 citations
This study investigated a novel computational strategy called Multivariate Framework for Functional Gene Network Enrichment Analysis (mFGNA), which enables effective functional pathway discovery in complex gene networks, providing mechanistic insights and potential translational targets in disease contexts.
Heewon Park, S. Imoto· Frontiers in Genetics· 0 citations
This work introduces an alternative criterion based on the persistent topological cycles in which each node participates---a measure of mesoscale integration that captures features beyond local connectivity---and demonstrates that persistent topology captures information about brain network control that scalar energy s...
Carter Sale, Marco Coraggio, Mengsen Zhang et al.· 0 citations
The proposed engGNN is highlighted as a robust, flexible, and interpretable framework for disease classification and biomarker discovery in high-dimensional omics contexts and provides interpretable feature importance scores that facilitate biologically meaningful discoveries, such as pathway enrichment analysis.
Tian-Tian Yang, Yuxuan Wang, Zhen-Wei Zhou et al.· Briefings in Bioinformatics· 0 citations
By modeling the many-to-many structure of kinase-substrate interactions, LIKA achieves high efficiency, even with limited data, while capturing network complexity, and reveals novel dysregulated kinases.
Lu-Jing Zhang, Andrew G. Demarco, Kimia Ghafari et al.· bioRxiv· 0 citations
Crohn's disease involves widespread functional network disruption and reorganization, particularly in interoceptive regions supporting sensory and emotional processing, particularly in interoceptive regions supporting sensory and emotional processing.
