Journal of Population Therapeutics and Clinical Pharmacology

Abstract

The study aimed to develop Simvastatin-loaded transdermal films for the treatment of hyperlipidemia and to examine the effect of polymer concentration on drug penetration. Methods: The transdermal films were prepared using the solvent evaporation method and evaluated for various physicochemical properties, including weight variation, thickness, drug content, moisture content, and folding endurance. Additionally, in vitro drug release studies and kinetic analyses were performed. Results: By using Melvern zetasizer the particle size was found in the range between 964.7 nm and 130.8 nm. A formulation with lower size of 130.8 nm was selected for further studies, and its surface charge of zeta potential was negative. The SEM image shows that nanoparticles were within the nano range The prepared simvastatin nano suspension incorporated films were of uniform weight. Thickness varied from 230.4 to 307.95 μm. The drug content in all formulations ranged from 90.09% to 97.16%. Moisture content was between 3.71% and 6.89%, while moisture uptake varied from 5.56% to 8.22%. Folding endurance results were satisfactory, with the F3 formulation exhibiting the highest drug release. Conclusion: The study concluded that among the many formulations tested, the F3 formulation was the best, with 90.2% drug release at 24 hours.