Causal relationship and pathogenic mechanism analysis of breast cancer and coronary heart disease based on mendelian randomization and transcriptome data analysis
The genetic causal relationship between BC and CHD in Asian populations is established for the first time, and the inflammation-immune-metabolism molecular axis mediating comorbidities is revealed, revealing the inflammation-immune-metabolism molecular axis mediating comorbidities.
BACKGROUND
Endocrine-disrupting chemicals (EDCs) are linked to coronary heart disease (CHD), but underlying mechanisms remain unclear. We aimed to identify EDC-related genes and evaluate their causal roles in CHD.
METHODS
We curated EDC-related genes from a compound-gene interaction database and integrated them with...
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