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Proteomic Pathways Linking Type 2 Diabetes Genetic Clusters to Cardiovascular Diseases: A Network Mendelian Randomisation Study

Shuang Liao Gabriel Chun Yin Sung Yiwen Liang Chen-Xi Li Shiu-Lun Au Yeung

Aug 2026 · Diabetes, obesity and metabolism · Vol 28, pp. 10428 - 10438 · 0 citations · 54 references

Medicine

TL;DR

This network Mendelian randomisation study delineates protein-mediated pathways linking cluster-stratified T2D genetic predisposition to cardiovascular risk, which can inform preventive strategies by stratifying individuals based on distinct biological pathways represented by these genetic clusters.

Abstract

Genetic clusters related to Type 2 diabetes (T2D) have differential impact on cardiovascular diseases (CVDs), although the underlying mechanisms, such as proteomic perturbation, remain unexplored. We conducted a network Mendelian randomisation (MR) study to identify proteomic mediators linking T2D genetic clusters and CVDs.

DOI PubMed Semantic Scholar

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