Open access
Targeted NLRP3 Silencing with Lipopolymer Nanocarriers for Precision Therapy in IL-1β-Mediated Autoinflammatory Diseases
Mohammad Nasrullah
A. Rajendran
K. C. Bahadur Remant
Burçak Bulut
Luv Modi
Pavlo Michailo Tsisar
Cezary Kucharski
Micol Romano
Lizzy Piskin
F. Garcia-Bournissen
H. Ostergaard
Sneha Suresh
Mohamed Osman
Erkan Demirkaya
Hasan Uludağ
Abstract
Objectives. Inflammatory diseases could arise from dysregulated innate immunity, often driven by pathogenic activation of the NLRP3 inflammasome, which promotes caspase-1-mediated maturation and secretion of interleukin-1β (IL-1β). While IL-1-blocking biologics...