This review examines epidemiology, clinical features, diagnostic challenges, and treatment strategies for older adults with bipolar disorder, requiring a balance between evidence-based pharmacological treatments, psychosocial support, and careful attention to comorbidities and functional status.
Abstract
Bipolar disorder (BD) in older adults is a signifi cant yet under-recognized mental health concern. The clinical presentation in this population often
diff ers from younger individuals, with increased cognitive impairment, comorbid medical conditions, and heightened sensitivity to medications.
Accurate diagnosis is frequently complicated by overlapping symptoms with neurodegenerative disorders and age-related mood changes. This
review examines epidemiology, clinical features, diagnostic challenges, and treatment strategies for older adults with bipolar disorder. Evidencebased pharmacological and psychosocial interventions are discussed, emphasizing the importance of individualized care to improve quality of
life and functional outcomes. Recognizing and addressing the unique needs of this population is crucial for eff ective management. Eff ective
management of bipolar disorder in older adults is multidimensional, requiring a balance between evidence-based pharmacological treatments,
psychosocial support, and careful attention to comorbidities and functional status. Individualized care plans, ongoing monitoring, and collaboration
among healthcare providers are essential to optimize outcomes and enhance quality of life.
Addressing the multifaceted diagnostic and pharmacotherapeutic challenges of OABD through dedicated age-specific clinical trials, comparative effectiveness studies, systematic evaluation of deprescribing strategies, and enhanced clinician awareness will be fundamental to improve outcomes for this understudied and expan...
Current evidence supports individualized use of MOUD while accounting for comorbidities, polypharmacy, and age-related physiologic changes, and future research should prioritize geriatric-specific screening tools, diagnostic frameworks, treatment protocols, and clinical outcomes.
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