Integrative Analysis of Oxidative Stress Biomarkers And Their ” Clinical correlates in Pediatric Type 1 Diabetes A MultiParametric Approach

Abstract

n this study, we used the neutrophil granulocytes functional activity model to examine oxidative stress indicators, antioxidant protection, lipid peroxidation, and T1D in children. According to research, children with type 1 diabetes show heightened lipoperoxidation and antioxidant defense system activation in response to reactive oxygen species (ROS) damage, which includes bidirectional alterations in non-enzymatic pathways. The development of tolerance to oxidative stress in children with compensated type 1 diabetes is indicated by the coordinated synthesis of reactive oxygen species and oxygen-dependent blood cell metabolism. In children with decompensated type 1 diabetes, it is indicated that the third stage of oxidative stress, which involves the depletion of insulin-producing β-cells, begins with a decrease in reactive oxygen species production, a decrease in the activation of the phagocyte oxygen-dependent metabolism, and incomplete phagocytosis mechanisms. The severity of metabolic problems in children with type 1 diabetes is influenced by the level of the antioxidant defense system's "respiratory explosion" of neutrophilic granulocytes.