Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate

RNA dysregulation as a determinant of aging and neurodegenerative vulnerability.

In the nervous system, aging causes deterioration of cellular and molecular processes that are associated with declines in cognition, sensory perception, and motor coordination. Aging is also the strongest risk factor for neurodegenerative disease, yet the mechanisms by which aging predisposes neurons to dysfunction re...

From aggregate structure to disease trajectory: the role of the proteostasis network

Abstract Neurodegenerative diseases are characterized by the accumulation of a small number of misfolded proteins, yet they differ markedly in cellular vulnerability and clinical outcome. We propose that this heterogeneity arises from the interaction between two largely orthogonal variables: the structural identities o...

ALPK3 gene addition to restore sarcomeric quality control

Lipid elongation as a hallmark of aging

Erosion of regenerative regulation: age-associated shifts in the skeletal muscle fiber epigenome and transcriptome

Together, these findings identify an age-associated regulatory shift, largely invisible in matched transcriptomic data, characterized by closing chromatin which reduces accessibility to hormone receptor binding sites and enhancer regions in the muscle fiber epigenome.

Age-Dependent Nonlinear Protein Aggregation: A Mathematical Model of Gut-Brain Axis Mediated Neurodegeneration.

The structural alterations due to protein misfolding, aggregation and clumping could lead to a number of pathological diseases. They have a considerable influence on the biological function of the intrinsically disordered proteins (IDPs) as well. The development of a comprehensive theory about neurodegenerative disease...