A Prognostic Model Based on Adipokine-Related Genes for Hepatocellular Carcinoma: Assessment of Patient Outcomes and Tumor Microenvironment Characterization
Jul 2026· Digestive Diseases and Sciences· Vol 71, pp. 5556 - 5574· 0 citations· 58 references
Medicine
TL;DR
An ARG-based prognostic model for HCC was established and preliminarily suggested that PGF may be involved in regulating the sensitivity of HCC cells toimatinib, and a preliminary basis for further investigation of ARG-relaterognostic assessment and PGF-mediated drug sensitivity.
This KIF20A/NDC80-based model is a reliable prognostic tool for HCC; its immunotherapeutic utility remains exploratory and requires prospective validation.
Yu Yan, Zhen-Guo Liu, Dawei Zhou et al.· Cancer Biomarkers· 0 citations
A lymphangiogenesis-related six-gene model enables clinically meaningful prognostic stratification of CESC and links lymphangiogenesis programs to distinct tumor immune phenotypes and therapeutic vulnerabilities.
Xi-Jing Fan, L. Chen, Jing Xu et al.· Frontiers in Genetics· 0 citations
Hepatocellular carcinoma (HCC) is one of the malignant tumors with high incidence and mortality rates worldwide. Given the poor prognosis of patients with HCC, it is crucial to explore the molecular mechanisms underlying HCC development and to evaluate prognostic markers. Differential expression analysis followed by un...
Yu-Xian Liu, Xing-Jie Chen, Jun-Yuan Zhang et al.· International Journal of Mol...· 0 citations
The results validate the biological significance of the model, highlight potential associations between lipid metabolism and the immune microenvironment in HNSCC, and provide a theoretical basis for further investigating metabolism-related therapeutic strategies.
Ting-Zhi Xie, Xin-Yi Sun, Jing Wang et al.· Oral Diseases· 0 citations
The adrenomedullin receptor signaling pathway plays a crucial role in tumor progression, yet its comprehensive implication in hepatocellular carcinoma (HCC) remains underexplored. This study aimed to develop and validate a multi-gene prognostic signature based on adrenomedullin receptor signaling-related genes (ARGs) a...
Dan Zhu, Siyi Zhong, Jiawei Hong et al.· Medicine· 0 citations
A four-gene hypoxia-related prognostic signature was established and successfully stratified patients into high- and low-risk groups and was associated with distinct metabolic and immune characteristics in HCC.
Chengting Wu, Yuanqin Du, Juhong Jia et al.· Discover Oncology· 0 citations
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