Colangitis biliar primaria en un varón joven con ictericia aislada : reporte de un caso clínico

Abstract

Its initial clinical presentation is usually insidious, with manifestations such as fatigue and pruritus in a significant percentage of cases, while overt jaundice is usually indicative of advanced disease. Diagnosis is based on a cholestatic pattern in liver function tests, the detection of specific autoantibodies—mainly antimitochondrial antibodies (AMA), present in 90–95% of cases—and the exclusion of other causes of cholestatic liver disease. First-line treatment is ursodeoxycholic acid, which improves transplant-free survival and slows disease progression. We present the case of a young male patient with isolated jaundice and weight loss, in whom the diagnosis of PBC was confirmed by positive AMA and liver biopsy. This case highlights the importance of recognizing this entity in atypical populations by age and sex, in order to initiate timely treatment and improve prognosis