Microgravity-Induced Osteocyte Dysfunction: An Osteocyte Mechanobiology Unit Framework

Osteocyte-Derived Extracellular Vesicles: Bridging the Gap in Skeletal Physiology and Pathophysiology

Research Status and Development Prospects of Osteocyte Microenvironment Regulating Bone Regeneration After Fracture

Osteocytes, the most prolific and longest lived resident cell population embedded in the mineralised skeletal matrix, have evolved from putative passive placeholders to active conductors of skeletal metabolism and regeneration. After bone fracture, the local osteocyte microenvironment, comprising the complex lacuno-can...

Ultrastructural and Proteomic Signatures of Mechanoadaptive Fibroblast Remodeling across Microphysiological and Mesoscale Shear Platforms

Rethinking osteocyte models in vitro: the need for mineralised extracellular matrix and network architecture

Osteocytes inhabit one of the most extreme cellular microenvironments in the human body: a hydrated, hierarchically structured mineralised extracellular matrix where lacunar confinement, canalicular connectivity, fluid transport and mechanics are inseparable from cell function. In vitro osteocyte models have rapidly ad...

Mechanotransduction in Bone - Role of the Osteocyte Network

A theory suggests that the subsequent actival ion of osteoclasts and osteoblasts dur ing remodeling, is a strain-regulated phenomenon, leading to reduced and enhanced canalicular flow, and the maintenance of a mechanically efficient architecture.

Mechanobiology of orofacial tissues: principles, mechanisms, and therapeutic applications

The orofacial system is constantly subjected to complex and dynamic mechanical forces and exhibits highly specialized mechanosensory and mechanoresponsive behaviors. However, current studies are mostly limited to single tissues or specific pathway analyses, which are insufficient to reveal a comprehensive mechanoregula...