Design rules and a reproducible evaluation protocol are contributed that jointly report quality, memory, and end-to-end speed, and a foundation for automated pipeline search under realistic single-GPU constraints is provided.
Abstract
Single-GPU deployment of 70B-parameter language models on an NVIDIA GPU is constrained by device memory, long-context throughput, and engineering integration cost. We cast single-GPU inference as a budget-aware design problem over these three axes and study how pruning, quantization, and KV-cache compression interact under realistic execution. Controlled ablations show that layer-wise pruning makes weight quantization more robust. KV-cache sparsification complements INT8 KV quantization by reducing memory without hurting decoding speed, while static vector quantizers often conflict with dynamic caching. Guided by these coupling results and explicit budget tracking, we assembled a practical pipeline and compressed a 70B model to about 33 GB, sustained about 57 tokens/s on 10k token prompts on a single A40, and kept absolute accuracy within 5% on common and reasoning benchmarks. We contribute design rules and a reproducible evaluation protocol that jointly report quality, memory, and end-to-end speed, and we provide a foundation for automated pipeline search under realistic single-GPU constraints.
The Mixture-of-Experts (MoE) architecture has become the dominant paradigm for scaling Large Language Models, yet its explosive parameter growth routinely overflows the GPU memory budget. Weight quantization offers a practical way to fit these models into limited GPU memory, but reducing precision below 4 bits causes s...
Lei Jiang, Jingwei Sun, Jun-Qing Lin et al.· Proceedings of the Internati...· 0 citations
The results reveal non-trivial interactions among compression methods: composable compression cannot be predicted from standalone techniques, compression rate alone does not reliably predict quality loss or runtime gain, expert pruning is the dominant degradation source, and average quality can hide workload and archit...
A. Benazir, Chen Chen, Rongxiao Qu et al.· 0 citations
TurboQuant-Bio, an open toolkit that compresses Evo 2’s weights and attention cache to four bits without calibration data, and serves both through fused kernels, proves near-lossless across perplexity spanning the tree of life, genomic classification, splice-site prediction, gene completion and clinically relevant vari...
Michail Patsakis, Alexandros Tzanakakis, I. Georgakopoulos-Soares· bioRxiv· 0 citations
Tensor parallelism is the only lever that improves latency (compression makes per-token latency worse), while compression is the only lever that multiplies capacity per dollar (16.5x, against 1.21x for an eightfold spend on GPUs).
The performance of single-GPU LLM inference is characterized by strong cross-layer interactions spanning model architecture, runtime scheduling, operator execution, and GPU microarchitecture. Unfortunately, a unified understanding of single-GPU LLM inference bottlenecks is still lacking due to two limitations: the lack...
Zong-Xing Zhao, Xiaqing Li, Ze-Kai Meng et al.· Proceedings of the Internati...· 0 citations
Three fundamental design principles are revealed that provide design-space guidance for architects designing the next generation of memory-accelerated LLM systems.
Corey Lammie, Hadjer Benmeziane, W. Simon et al.· 0 citations
A new computational approach reveals how cells communicate to assemble into tissues. This could accelerate stem cell engineering, improve disease models, and inform therapies.
Microsoft Research Blog· microsoft.comOct 15, 2026
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
MIT News · Artificial Intelligence· news.mit.eduSep 24, 2026