A covalent tumor-targeted theranostic system for NIR imaging-guided photodynamic-ferroptosis synergistic therapy of lung cancer

Yurong Fan Hongyuan Wen Zhitao Zhu Chaoxiang Cui Yu-Qi Zhang Zhongsheng Zhao Miao Li Yiming Feng Mei Hu Xingxiang Ren Zhengzhong Lv Zhixin Han Haibin Shi Guohua Fan

Jul 2026 · Science China Materials · Vol 69, pp. 5180 - 5190 · 0 citations · 38 references

TL;DR

DIR-CDF can specifically target integrin αvβ3-positive NSCLC and is covalently anchored within the tumors through the specific reaction between 1,3-cyclohexanedione and sulfenic acid, which significantly enhances the accumulation and retention of dIR-CDF in tumors.

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