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Open access Sep 2026

EGFR-Targeted Nanoparticle Delivery of Osimertinib for Triple-Negative and Metastatic Breast Cancer Therapy

Background/objective: Osimertinib, an EGFR-targeted agent approved for metastatic NSCLC, shows promise for triple-negative breast cancer due to EGFR overexpression in aggressive tumors. However, oral administration limits tumor delivery and causes systemic side effects. This study aimed to develop chitosan-coated PLGA...

Iman M. Alfagih, Maryam Alfagih, Alanood S. Almurshedi et al. · 0 citations
Open access Jan 2026

Targeted Delivery of Triptolide Via Folate-Functionalized Pluronic Micelles Enhances Anti-Melanoma Activity by Inducing Reactive Oxygen Species Accumulation.

Melanoma remains a highly lethal malignancy, often associated with limited therapeutic efficacy and substantial systemic toxicity caused by conventional chemotherapy. Triptolide (TP) exhibits potent antitumor activity, but its clinical application is limited by poor aqueous solubility and a narrow therapeutic window. I...

Gen-Ying Zhuang, Yan-Li Chen, Xiu-Li Gao et al. · 0 citations
Open access Aug 2026

Multifunctional nanoparticles for co-delivery of elacridar and paclitaxel for breast cancer local treatment.

In an in vivo model of breast cancer, intraductal H-NPs reduced tumor incidence and volume compared to a drug solution, and increased the mammary tissue-to-plasma ratio of paclitaxel by 105-fold, supporting an improved tissue retention, support H-NPs as promising platforms for localized breast cancer therapy.

J. S. Passos, G. C. Salata, G. B. de Melo et al. · 0 citations
Open access Sep 2026

Folate-Targeted polymeric micelles enhance the anti-glioma efficacy of pterostilbene in an orthotopic rat model

The clinical translation of Pterostilbene, a neuroactive stilbene with broad therapeutic potential, is hampered by its poor aqueous solubility and insufficient brain accumulation. To address these limitations, we developed a folate receptor-targeted polymeric micelle system (F–Pt/M) using poly (ethylene glycol)-block-p...

Xiao-Bo Yang, Yu-Ze Sun, Huan Jin et al. · 0 citations
Open access Aug 2026

Experimental evaluation of Nilotinib and Paclitaxel co-delivered via albumin nanoparticles as a therapeutic strategy for lung squamous cell carcinoma

Chemotherapy remains the primary treatment for advanced lung squamous cell carcinoma (LUSC); however, its severe toxic side effects significantly limit therapeutic efficacy. There is an urgent clinical need to integrate molecular targeting with chemotherapy to enhance treatment outcomes. Consequently, this study develo...

Xing Wei, Lei-Yu Cao, Yan Gao et al. · 0 citations
Open access Sep 2026

PSMA-Targeted Liposomes for Therapeutic Delivery into a Prostate Cancer Cell Model

Findings provide proof-of-concept evidence that PSMA-targeted DUPA-PEG LIPOs can facilitate Talazoparib delivery and, particularly in combination with BI 2536, may enhance antitumor activity in PCa models.

Miguel Ferreira, Neelum Aziz Yousafzai, Lital Ben Naim et al. · 0 citations

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