TL;DR
A ROS-responsive nanosystem (TK-MLP@SR NPs) containing SKN and RSV is engineered, introducing a novel plaque environment-activated prodrug platform, providing valuable insights for clinical translation of AS therapy.
Atherosclerosis is a gradual process that occurs on the artery walls caused by multiple drivers, such as the presence of oxidative stress, chronic inflammation and disorganized lipid metabolism resulting in increased plaque formation and life-threatening cardiovascular disease. Due to their poor bioavailability, rapid...
This hierarchical system provides a promising therapeutic strategy for periodontal regeneration in diabetic periodontitis by integrating redox-responsive actuation, targeted immunometabolic regulation, and sustained osteoimmunomodulation.
AIMS The treatment of ulcerative colitis(UC) remains a significant challenge contributing to the growing global healthcare burden. Efficient clearance of apoptotic cells is a crucial mechanism for tissue repair and maintenance of homeostasis following inflammatory damage. Macrophages critically govern the balance betwe...
The chronic recurrence of psoriasis is driven by a self-amplifying inflammatory cascade in which oxidative stress and mitochondrial metabolic dysfunction reinforce each other, and single-target conventional therapies often fail to break this cycle. Here, we present a micro-nano hybrid system, Mito-Ce, constructed by co...
The hepatoprotective effects of Ebselen also extend to include reducing hepatic lipid accumulation and preventing steatosis induction in rodent models of liver fibrosis.
Proteasome inhibitors, particularly bortezomib (BTZ) which induces oxidative stress, remain the cornerstone of multiple myeloma (MM) therapy. However, resistance driven by metabolic reprogramming and redox adaptation limits their long-term efficacy. Here, we identify a cholesterol biosynthesis-dependent antioxidant mec...
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