An Undescribed Ingenane Glucoside Isolated from the Roots of Euphorbia fischeriana Steud and Its Anti-inflammatory Activity

Abstract

Abstract: A new compound, ingenol 3-O-β-D-glucopyranoside (1) was isolated from the roots of Euphorbia fischeriana Steud. (Euphorbiaceae), together with four known compounds (2−5). The structure of compound 1 was characterized by a combination of spectroscopic techniques and X-ray crystallography. Moreover, biological evaluation revealed that compound 1 exhibited potent inhibitory effect on NO production in lipopolysaccharide-stimulated RAW 264.7 macrophages, with IC50 value of 25.24 ±3.48 μM.