Sep 2026· Journal of chromatography. B, Analytical technologies in the biomedical and life sciences· Vol 1284, pp.
125303
· 0 citations
Medicine
TL;DR
The specific SRM transition of 13C₂,d₄-cyclosporine A was characterized for the first time, and a robust LC-MS/MS method was established for the simultaneous quantification of the six target drugs in human whole blood.
This validated LC-MS/MS method allows simultaneous analysis of multiple anti-TB drugs in plasma, serum, and saliva, facilitating clinical and research applications and demonstrated linearity, selectivity, and minimal carry-over.
M. Bolhuis, E. M. Jongedijk, O. Akkerman et al.· Therapeutic Drug Monitoring· 0 citations
Purpose With the expanding use of therapeutic monoclonal antibodies (mAbs) in inflammatory bowel disease (IBD), there is a critical need for robust, multiplex analytical tools to support therapeutic drug monitoring (TDM) and pharmacokinetic studies. This study aimed to develop and validate a rapid and sensitive liquid...
Yan-Bao Zhang, Na Wang, Wei-Yang Zheng et al.· Drug Design, Development and...· 0 citations
A sensitive and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantification of ibuprofen in plasma to investigate the pharmacokinetics of ibuprofen after oral administration of ibuprofen sustained-release capsules.
Mei-Ah Yang, Kui He, Yu-Jie Mo et al.· Acta Chromatographica· 0 citations
The established LC-MS/MS method provides a reliable alternative to immunoassays, with a wide dynamic range suitable for TDM and personalized dose interval adjustments in patients receiving dupilumab.
Kun-Peng Yang, Jian-Hua Wu, Cheng-Ming Yang et al.· Journal of Pharmaceutical an...· 0 citations
High-resolution mass spectrometry (HRMS) is a rapidly growing technique available in the clinical laboratory that is more sensitive, specific, and comprehensive for quantitative and qualitative drug analysis compared to traditional immunoassay screening. A 66 drug and metabolite qualitative panel, with emphasis o...
Bo Zhong, Danielle A. Katz, D. Payto et al.· Clinical Chemistry· 0 citations
Waters provides a comprehensive immunosuppressant kit, which includes the MassTrak™ Immunosuppressant Calibrator, Quality Control, and Internal Standard sets, along with a validated analytical method. To optimize performance for our specific clinical needs, the manufacturer’s protocol was modified to reduce matri...
Yi Xiao, Zara Jalali, E. Leung· Clinical Chemistry· 0 citations
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