The data suggest that the high viral replication and the high induction of pro-inflammatory cytokines in the human lung cells infected with HP H5N1 avian influenza viruses may enhance pathogenicity in the infected humans as compared to seasonal H3N2 influenza viruses.
The first outbreak of highly pathogenic avian influenza (HPAI) H5N8 virus in India occurred in 2016, initially affecting wild birds and later spreading to domestic and commercial chickens, causing severe morbidity and mortality. To investigate the host immune response, Specific Pathogen-Free (SPF) chickens were experim...
Boopathi Ponnusamy, Manoj Kumar, H. Murugkar et al.· Comparative Immunology, Micr...· 0 citations
Single-cell transcriptomics is used to examine the cellular responses of human and chicken cells 24 h after infection with the zoonotic H9N2 virus to identify candidate host factors and pathways associated with viral replication and provide insights into the transcriptional responses.
Fanny Oldensand, N. Rafati, V. van Hoef et al.· Virology· 0 citations
Highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b virus continues to spread globally and sporadically transmits from avian reservoirs to mammalian hosts. In May 2024, H5N1 infections in young goats and alpacas in the United States were reported. Nevertheless, the overall susceptibility of camelids to clad...
Jacob Schön, A. Breithaupt, N. Halwe et al.· Emerging Infectious Diseases· 0 citations
The emergence of novel influenza strains through reverse-zoonotic transmission poses potential risks to both animal and human health. This study characterized a naturally isolated reassortant canine H3N2 virus carrying the matrix (M) gene of 2009 pandemic H1N1 virus. In vitro experiments revealed that the M variant c...
Human adenovirus type 7(HAdV-7) is a major cause of severe pediatric pneumonia, but the mechanisms linking viral infection to pulmonary immune remodeling and lung pathology remain incompletely understood. Progress has been limited by the lack of physiologically relevant animal models that recapitulate human suscept...
Zhong-Ying Yang, Zi-Jun Meng, Ming-Ling Wan et al.· Frontiers in Immunology· 0 citations
This review unites historical milestones, structural insights, epidemiological data, and recent cross-species findings to better define the current landscape of risk and transmission of HPAI viruses.
Leila Wogick, S. Goyal· Clinical Microbiology Review...· 0 citations
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