A case of a 41-year-old man who had experienced right limb weakness for 3 months and was diagnosed with pilocytic astrocytoma, who received concurrent CRT followed by temozolomide maintenance chemotherapy, and has maintained sustained partial remission.
Abstract
Adult brainstem gliomas (BSGs) are rare malignant tumors of the central nervous system (CNS) that are difficult to resect completely via surgery, so chemoradiotherapy (CRT) is the primary treatment modality. However, there is substantial interpatient variability in therapeutic response to CRT among patients with BSGs. Here we present a case of a 41-year-old man who had experienced right limb weakness for 3 months. Brain MRI showed a solid-cystic mass in the brainstem, involving the medulla oblongata and the cervical spinal cord. The pathological diagnosis was pilocytic astrocytoma, CNS WHO Grade 1. Since the solid-cystic mass in the brainstem was unresectable, the patient received concurrent CRT followed by temozolomide (TMZ) maintenance chemotherapy. No significant change in tumor size was observed after concurrent CRT. Notably, 15 months after radiotherapy (19 months since the initial diagnosis), the tumor size decreased significantly. Up to the latest follow-up, the patient has maintained sustained partial remission.
Pediatric intramedullary low-grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross-total resection is frequently unfeasible due to the infiltrative nature of these lesions. To de...
O. Sergeenko, Segev Gabay, Jonathan Roth et al.· Pediatric Blood & Cancer· 0 citations
A 37-year-old woman who presented with long-standing right temporal-parietal headache and acute worsening with vomiting is reported, highlighting a rare pattern of primary extracranial extension in GBM and suggesting direct contiguous transdural invasion as a plausible route of spread in the absence of prior interventi...
Jian-Hang Lin, Jia-Yi Lin, Jia-Na Zhang et al.· Frontiers in Medicine· 0 citations
Brain metastases from non-small cell lung cancer are typically managed with local therapies, such as surgery and radiotherapy, whereas systemic treatments have historically demonstrated limited efficacy in the intracranial setting. Immune checkpoint inhibitors, particularly programmed cell death-1 inhibitors, have rece...
Ryuichi Noda, A. Akabane, Mariko Kawashima et al.· NMC Case Report Journal· 0 citations
Introduction: Uterine carcinosarcoma, also known as malignant mixed Müllerian tumor, is a rare and highly aggressive malignancy. Central nervous system involvement is exceptional, with very few cases of brain metastases reported in the literature. In this context, individualized evaluation with emphasis on immunohistoc...
Nerleschka Omayling Indriago Mejias, María Gabriela Sánchez Páez, S. Rojas· Revista Chilena de Neurociru...· 0 citations
Abstract Spinal cord diffuse midline gliomas (DMGs) are rare World Health Organization (WHO) grade IV neoplasms with a poor prognosis. Due to the limited number of reported cases and the absence of standardized treatment protocols, most patients undergo biopsy or subtotal resection followed by radiotherapy. We report a...
Rakesh Vashishta, Smily Sharma, B. Thomas et al.· Indian Journal of Radiology...· 0 citations
A young adult who developed osseous and hepatic metastases from an IDH-wildtype grade 4 astrocytic glioma is described, which shows a rhabdoid high-grade tumour whose profile matched the primary (GFAP positive, IDH1 negative, p53-mutant).
Muneer Ahmed, Muhammad Irtiza Irshad, Adeeba Zaki et al.· JPMA. The Journal of the Pak...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
