Progression of multiple sclerosis The role of microglia and neurons

Progression of multiple sclerosis The role of microglia and neurons

Progression of multiple sclerosis The role of microglia and neurons

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.

A Blood-Based Synaptic Biomarker in Neuronally-Enriched Extracellular Vesicles Predicts Disability Progression in Progressive Multiple Sclerosis

NEV synaptopodin is identified as a prognostic and longitudinal, blood biomarker of synaptic integrity in PMS, particularly SPMS, complementing NfL.

Chronic low-grade inflammation, genetic susceptibility, and the risk of multiple sclerosis: a prospective cohort study

The association of LGI with incident MS risk and MS-related brain structural measures in a large prospective cohort suggests that peripheral inflammation may serve as a potential marker for identifying individuals at elevated MS risk, warranting further investigation in interventional studies.

Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer’s vulnerability